Why is my mouse not locked into the middle of my screen?

[Luca Tribs]

I assume I accidentally clicked a wrong button but I'm trying to play a game and the mouse was going off into my 2nd monitor to my left instead of being invisible and staying at the center. I already tried F9 but that doesn't seem to work. I assume some key or setting will be able to fix it. I feel like I'm missing something simple but I'd appreciate any help.

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