Top Left Corner of My Screen Not Responsive to Mouse Clicks.

[Windows 10]

This problem has only occurred recently, within the last two months. I'm not sure when it exactly started. System information: Custom built PC with 1660 super, 12400f, and Windows 10. Other people have had this problem before, but not many people have a single consistent fix. It's often times something unique. My problem is that, on my main monitor only, I occasionally lose responsiveness in the top left corner of the screen and can no longer use my mouse to click in a rectangle shaped area. (The rectangle of no responsiveness is longer than it is tall). Again, this only happens occasionally,

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