I got a stop running this script pop up. Do I click 'Yes' or 'No'?

[Cynthia -]

I got a stop running this script message earlier today. I went into into IE options and selected the Disable script debugging option but the pop up is still there. My question is do I click 'Yes' or 'No' to the stop running this script error message? I am not able to x out of the dialog box.

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