Mouse stops being able to click on things

[Microsoft Windows]

My mouse has suddenly stopped clicking on things. But its not the mouse thats the problem because I bought a new one and have the same issues. I can click on some things and cant click on others and the only way to temporarily fix it is switching the port the mouse is plugged into and restart my pc but then over time while using my pc it will slowly stop clicking on things again and its different things each time. Sometimes I can click onto some discord servers and not others or i can open the server but cant join a call or open settings or sometimes cant click discord at all and can happen fo

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